Selected Publications:

Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1 deficient mice. Cell 1997; 89: 629-639.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin regulates the processing of APP C-terminal fragments and the generation of amyloid §-protein in ER and Golgi. Biochemistry 1998; 37: 16465-16471.

Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci USA 1999; 96: 6959-63.

Yu H, Kessler J, Shen J. Heterogeneous populations of ES cells in the generation of a floxed Presenilin-1 allele. Genesis, 2000; 26: 5-8.

Handler M, Yang X, Shen J. Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 2000; 127: 2593-2606

Yoo AS, Cheng I, Chung, S, Grenfell TZ, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim T. Presenilin-mediated molulation of capacitative calcium entry. Neuron 2000, 27: 561-72.

Yang X, Handler M, Shen J. Role of presenilin-1 in murine neural development. Annals NY Acad Sci 2000; 920: 165-170.

Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. Alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci USA 2001; 98: 9110-5.

Yu H, Saura C, Choi S, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel E, Kirkwood A,
Shen J. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 2001; 31: 713-26.

Fujiwara H, Hasegawa M, Dohmae N, Kawashia A, Masliah E, Goldberg MS, Shen J, Takio K, Iwasubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002; 4: 160-4.

Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet M, Maidment NT, Levine MS, Shen J. Parkin-Deficient Mice Exhibit Nigrostriatal Deficits but not Loss of Dopaminergic Neurons. J Biol Chem 2003; 278: 43628-35.

Yang X, Klein R, Tian X, Cheng H, Kopan R, Shen J. Notch Activation Induces Apoptosis in Neural Progenitor Cells through a p53-Dependent Pathway. Dev Biol 2004; 269: 81-94.

Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Klose J, and Shen J.  Mitochondrial Dysfunction and Oxidative Damage in Parkin-Deficient Mice. J Biol Chem 2004; 279: 18614-22.

Saura CA, Choi S, Beglopoulos V,  Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher III RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration. Neuron 2004; 42: 23-36.*
*See associated minireview in Neuron 2004; 42: 189-92.

Shen J, Cookson MR. Mitochondria and Dopamine: New Insights into Recessive Parkinsonism. Neuron 2004; 43: 301-4.

Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD and Shen J. Reduced B-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knockout Mice. J Biol Chem 2004, 279: 46907-14.

Pan Y, Lin M, Tian X, Cheng H, Gridley T, Shen J, Kopan R. γ-Secretase functions through Notch signaling to maintain the lineally related skin appendages but is not required for patterning or their initial morphogenesis. Dev Cell 2004, 7: 731-743.

Shen J.  Protein kinases linked to the pathogenesis of Parkinson’s disease.  Neuron 2004, 44: 575-7.

Beglopoulos V and Shen J. Gene-targeting technologies for the study of neurological disorders. Neuromolecular Med 2004, 6: 13-30.

Goldberg MS, Pisani A, Haburcak M, Vortherms, TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P and Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1. Neuron 2005, 45: 489-96.*
*See accompanying preview in Neuron 2005, 45: 479-484.

Wines-Samuelson ME, Handler M and Shen J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol 2005, 277: 332-346.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, and Parker EM. Characterization of the reconstituted gamma-secretase complex from Sf9 co-expressing presenilin-1, nacastrin, Aph-1a, and pen-2. Biochemistry 2005, 44: 4450-4457.

Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, da Costa CA, Vincent B, Ring S, D'Adamio L, Shen J, Muller U, Hyslop P, Checler F. Presenilin dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 2005,46:541-554.

Wines-Samuelson M and Shen J. Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist 2005,11:441-51.

Saura CA, Chen G, Malkani S, Choi S, Takahashi RH, Gouras GK, Kirkwood A, Morris RGM and Shen J. Conditional inactivation of presenelin-1 prevents amyloid accumulation and temporarily rescues associative and working memory impairments in APP transgenic mice. J Neurosci 2005, 20:6755-64.

Sun X, Beglopoulos V, Mattson M and Shen J. Hippocampal memory impairments caused by familial Alzheimer’s disease-linked M146V mutation. Neurodegenerative Diseases 2005, 5:6-15.

Pan Y, Liu Z, Shen J and Kopan R. Notch 1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol 2005, 286(2):472-82.

Grimm MOW, Grimm HS, Patzold AJ, Zinser EG, Halonen R, Duering M, Tschape JA, Muller U, De Strooper B, Shen J, Hartmann T.  Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol 2005, 7(11): Letter.

Beglopoulos V and Shen J. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease. Trends Pharm Sci 2006, 27(1):33-40.

Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey M,  Kopan R, and Shen J. Notch1 Signaling Influences V2 Interneuron and Motor Neuron Development in the Spinal Cord. Dev Neurosci 2006, 28:102-117.

Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Shen J, and Calabresi P. Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to
energy metabolism impairment: Role of Na+/K+ ATPase. Neurobiol of Dis 2006, 23:54-60.

Shen J., Kelleher RJ 3rd. The presenilin hypothesis of Alzheimer’s disease: Evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci USA 2007, 104(2):409.

Yamaguchi H and Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular Neurodegeneration 2007, 2:10.

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, and Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007, 104:11441-6.

Maraver A., Tadokoro CE, Badura ML, Shen J, Serrano M, and Lafaille JJ. Effect of Presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. Blood 2007, 110(9):3218-25.

Del Barrio MG, Taveira-Marques R, Muroyama Y, Yuk D, LiS, Wines-Samuelson M, Shen J, Smith HK, Xiang M, Rowitch D, and Richardson WD. A regulatory network involving Foxn4, Mash-1 and Delta-like 4/Notch-1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development 2007, 134(19):3427-36.

Cookson MR, Dauer W, Dawson T, Fon E, Guo M, Shen J. The roles of kinases in familial Parkinson’s disease. J. Neurosci 2007, 27(44):11865-8.

Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC. Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci U S A. 2008, 105(3):979-984.

Kim WY and Shen J. Presenilins are required for maintenance of neural stem cells in the developing brain. Molecular Neurodegeneration 2008, 3:2.

Gautier CA, Kitada T, Shen J. Loss of PINK1 Causes Mitochondrial Functional Defects and Increased Sensitivity to Oxidative Stress. Proc Natl Acad Sci U S A. 2008, in press.