Mary E. Wines-Samuelson, Ph.D.
mwines@rics.bwh.harvard.edu
(617)525-5198

BIOGRAPHICAL SKETCH

POSITION TITLE: Research Fellow

EDUCATION:

PROFESSIONAL EXPERIENCE:

HONORS and AWARDS:

PUBLICATIONS:

Original Articles

1. Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL. Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial expression associated with Cryposporidium parvum infection. Infect. Immun. 1995; 66(3): 1045-56.
2. Wines ME, Tiffany A, Holdener BC. Physical localization of the mouse Aryl hydrocarbon receptor nuclear translocator-2 (Arnt2 ) gene within the c112K deletion. Genomics 1998; 51(2): 223-32.
3. Wines ME, Shi Y, Lindor M, Holdener BC. Physical localization of the mesoderm development (mesd) functional region. Genomics 2000; 68(3): 322-29.
4. Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC. Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. Genomics 2001; 72(1): 88-98.
5. Giese KP, Friedman E, Telliez JB, Fedorov NB, Wines M, Feig LA, Silva AJ. Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology 2001; 41(6): 791-800.
6. Barrow LL, Wines ME, Romitti PA, Holdener BC, Murray JC. Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts. Teratology 2002; 66(2): 85-90.
7. Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell 2003; 112(3): 355-67.
8. Wines ME, Handler M and Shen J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev. Biol.  2005; 277: 332-346.
9. Wines ME and Shen J.  Presenilins in the developing, adult, and aging cerebral cortex.  Neuroscientist 2005; 11(5): 441-451.
10. Yang X, Tomita T, Wines ME, Beglopoulos V, Tansey MG, Kopan R, and Shen J.  Notch1 signaling influences V2 interneuron and motor neuron development in the spinal cord.  Dev. Neurosci. in press.
    

Abstracts

1. Wines M, Tiffany A, Holdener BC. Genetic analysis of mesoderm induction in mice. 10th International Mouse Genome Conference, 1996 (poster presentation)
2. Wines M, Rosenquist T, Tiffany A, Holdener BC. msd is required for mesoderm induction and early patterning in the mouse embryo; Pattern Formation During Development Cold Spring Harbor Symposium, and Society for Developmental Biology, Northeast Regional Developmental Biology Conference,1997 (poster presentations)
3. Wines M, Tiffany A, Holdener BC. Phenotypic characterization and physical localization of the msd (mesoderm development) mutation in mice. 11th International Mouse Genome Conference, 1997 (poster presentation)
4. Wines ME, DeRossi C, Shi Y, Holdener BC. Identifying candidate genes and new phenotypes for the proximal albino deletions. Mouse Molecular Genetics Cold Spring Harbor Meeting (1998) and 12th International Mouse Genome Conference, 1998 (poster presentation and platform talk, respectively)
5. Wines ME, DeRossi C, Shi Y, Holdener BC. Molecular and phenotypic analysis of the mesoderm development (mesd) and thymus development functional intervals on mouse chromosome 7. Society for Developmental Biology, Northeast Regional Developmental Biology Conference, 1998 (poster presentation)
6. Wines ME, Shi Y, Holdener BC. The mesoderm development (mesd) interval contains two novel genes highly conserved in humans. Society for Developmental Biology, Northeast Regional Developmental Biology Conference, 1999 (platform talk).
7. Wines ME, Handler M, Shen J. Role of Presenilin-1 in Cortical Lamination and Survival of Cajal-Retzius Neurons.  6th International AD/PD Conference, 2003 (poster presentation).
   

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