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Angela Ho, Ph.D.
aho4@partners.org
(617)525-5129

BIOGRAPHICAL SKETCH

POSITION TITLE: Instructor

EDUCATION:

1991 State University of New York at Binghamton
1998 Mount Sinai School of Medicine, New York - Ph.D. Neuroscience
2005 University of Texas at Southwestern, Postdoctoral

PROFESSIONAL EXPERIENCE:

1991-1993

Research Technician, Dept. of Neuro-Oncology, Memorial Sloan Kettering Cancer Center, New York (Supervisor: Dr. Jerome Posner)
1993-1998
 Graduate Student, Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York (Mentor: Dr. Mariann Blum)
1998-1998
 Postdoctoral Fellow, Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York (Mentor: Dr. Mariann Blum)
1999-2005
 Postdoctoral Fellow, Center for Basic Neuroscience, University of Texas at Southwestern (Supervisor: Dr. Thomas Sudhof)
2005-2006 Assistant Instructor, Center for Basic Neuroscience, University of Texas at Southwestern
(Supervisor: Dr. Thomas Sudhof)
2006-2007 Instructor, Center for Basic Neuroscience, University of Texas at Southwestern (Supervisor: Dr. Thomas Sudhof)
2007-present Research Associate, Center for Neurologic Diseases, Department of Neurology, Brigham & Women’s Hospital
2007-present Instructor, Harvard Medical School

HONORS and AWARDS:

1996-1997
Developmental Biology Training Grant, Mount Sinai School of Medicine
1999-2002
National Research Service Award, NIA, Role of Mints in Synaptic Vesicles and APP Trafficking, F32-AG05844
2006-2011
 Mentored Research Scientist Development Award, NIA, Mints: Adaptor Proteins Coupling APP of Alzheimer’s Disease to the Synapse, K01 AG027311-01


SELECTED PUBLICATIONS:

  1. Dalmau J, Graus F, Cheng NK, Rosenblum MK, Ho A, Canete A, Delattre JY, Thompson SJ, Posner JB (1995) Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer 75:99-109.
  2. Ho A, Gore AC, Weickert CS, Blum M (1995) Glutamate regulation of GDNF gene expression in the striatum and in primary striatal astrocytes. NeuroReport 6:1454-1458.
  3. Gore AC, Ho A, Roberts JL (1995) Translational efficiency of gonadotropin-releasing hormone mRNA is negatively regulated by phorbal ester in GT1-7 cells. Endo 136:1620-1625.
  4. Gore AC, Yeo TT, Ho A, Roberts JL (1997) Post-transcriptional regulation of the gonadotropin-releasing hormone gene in GT1-7 cells. J Neuroendo 9:271-277.
  5. Ho A, Blum M (1997) Regulation of astroglial-derived dopaminergic neurotrophic factor gene expression by interleukin-1? in the striatum of young and middle-aged mice. Exp Neurol 148:348-359.
  6. Ho A, Blum M (1998) Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease. J Neurosci 18:5614-5629.
  7. Garcia de Yebenes E, Ho A, Damani T, Fillit H, Blum M (1999) Regulation of the heparan sulfate proteoglycan, perlecan, by injury and interleukin-1alpha. J Neurochem 73:812-820.
  8. Sugita S, Ho A, S?dhof TC (2001) NECABs A family of neuronal Ca2+-binding proteins with an unusual domain structure and a restricted expression pattern. Neuroscience 112:51-63.
  9. Ho A, Morishita W, Hammer RE, Malenka RC, S?dhof TC (2003) A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc Natl Acad Sci USA 100:1409-1414.
  10. Ho A and S?dhof TC (2004) Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid beta precursor protein cleavage. Proc Natl Acad Sci USA 101:2548-53.
  11. Dulubova I, Ho A, Huryeva I, S?dhof TC, Rizo J (2004) Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. Biochemistry 43:9583-8.
  12. Ho A, Morishita W, Atasory D, Liu X, Tabuchi K, Hammer RE, Malenka RC, S?dhof TC (2006) Genetic analysis of Mint/X11 proteins: Essential presynaptic functions of a neuronal adaptor protein family. J Neurosci 26:13089-13101.
  13. Atasoy D, Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, S?dhof TC (2006) Deletion of CASK produces lethality with impaired synaptic function. Proc Natl Acad Sci USA 104:2525-2530.

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