PROFESSIONAL EXPERIENCE:
| 1996–2002 |
Researcher at JAPAN TOBACCO Inc. |
| 2002–2006 |
Research assistant at University of Tokyo |
| 2006-present |
Postdoctoral fellow, Center for Neurologic Diseases,
Department of Neurology, Brigham and Women’s Hospital |
PUBLICATIONS:
1. Watanabe H, Saitoh K, Kameda T, Murakami M, Niikura Y,
Okazaki S, Morishita Y, Mori S, Yokouchi Y, Kuroiwa A, and
Iba H. Chondrocytes as a specific target of ectopic Fos expression
in early development. Proc Natl Acad Sci U S A. 94: 3994-3999.
1997.
2. Kameda T, Watanabe H, and Iba H. C-Jun and JunD suppress
maturation of chondrocytes. Cell Growth Differ. 8: 495-503.
1997.
3. Murakami M, Sonobe MH, Ui M, Kabuyama Y, Watanabe H, Wada
T, Handa H, and Iba H. Phosphorylation and high level expression
of Fra-2 in v-src transformed cells: a pathway of activation
of endogenous AP-1. Oncogene. 14: 2435-2444. 1997.
4. Murakami M, Watanabe H, Niikura Y, Kameda T, Saitoh K,
Yamamoto M, Yokouchi Y, Kuroiwa A, Mizumoto K, and Iba H.
High-level expression of exogenous genes by replication-competent
retrovirus vectors with an internal ribosomal entry site.
Gene. 202: 23-29. 1997.
5. Nakamura M, Yokoyama M, Watanabe H, and Matsumoto T. Molecular
cloning, organization and localization of the gene for the
mouse neuropeptide Y-Y5 receptor. Biochim Biophys Acta. 1328:
83-89. 1997.
6. Nakamura M, Watanabe H, Kubo Y, Yokoyama M, Matsumoto
T, Sasai H, and Nishi Y. KQT2, a new putative potassium channel
family produced by alternative splicing. Isolation, genomic
structure, and alternative splicing of the putative potassium
channels. Receptors Channels. 5: 255-271. 1998.
7. Yokoyama M*, Watanabe H*, and Nakamura M. Genomic structure
and functional characterization of NBPhox (PMX2B), a homeodomain
protein specific to catecholaminergic cells that is involved
in second messenger-mediated transcriptional activation. Genomics.
59: 40-50. 1999. (*equally contributed)
8. Watanabe H, Nagata E, Kosakai A, Nakamura M, Yokoyama
M, Tanaka K, and Sasai H. Disruption of the epilepsy KCNQ2
gene results in neural hyperexcitability. J Neurochem. 75:
28-33. 2000.
9. Akiyama K, Watanabe H, Tsukada S, and Sasai H. A novel
method for constructing gene-targeting vectors. Nucleic Acids
Res. 28: E77. 2000.
10. Yamamichi-Nishina M, Ito T, Mizutani T, Yamamichi N,
Watanabe H, and Iba H. SW13 cells can transition between two
distinct subtypes by switching expression of BRG1 and Brm
genes at the post-transcriptional level. J Biol Chem. 278:
7422-7430. 2003.
11. Higuchi T, Orita T, Nakanishi S, Katsuya K, Watanabe
H, Yamasaki Y, Waga I, Nanayama T, Yamamoto Y, Munger W, Sun
HW, Falk RJ, Jennette JC, Alcorta DA, Li H, Yamamoto T, Saito
Y, and Nakamura M. Molecular cloning, genomic structure, and
expression analysis of MUC20, a novel mucin protein, up-regulated
in injured kidney. J Biol Chem. 279: 1968-1979. 2004.
12. Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe
H, Minoguchi S, Kobayashi N, Kimura S, Ito T, Yahagi N, Ichinose
M, Omata M, and Iba H. (2005) The Brm gene suppressed at the
post-transcriptional level in various human cell lines is
inducible by transient HDAC inhibitor treatment, which exhibits
antioncogenic potential. Oncogene. 24: 5471-5481. 2005.
13. Watanabe H, Mizutani T, Haraguchi T, Yamamichi N, Minoguchi
S, Yamamichi-Nishina M, Mori N, Kameda T, Sugiyama T, and
Iba H. SWI/SNF complex is essential for NRSF-mediated suppression
of neuronal genes in human non-small cell lung carcinoma cell
lines. Oncogene. 25: 470-479. 2006.
14. Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M,
Mizutani T, Watanabe H, Shiogama K, Fujishiro M, Okazaki T,
Yahagi N, Haraguchi T, Fujita S, Tsutsumi Y, Omata M, Iba
H. Frequent loss of Brm expression in gastric cancer correlates
with histologic features and differentiation state. Cancer
Res. 67: 10727-35. 2007
15. Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi
T, Mizutani T, Sakurai K, Fujita S, Izumi T, Isobe T, Iba
H. Brm transactivates the telomerase reverse transcriptase
(TERT) gene and modulates the splicing patterns of its transcripts
in concert with p54 nrb. Biochem J. in press.
