Hiroo Yamaguchi, M.D., Ph.D.
hyamaguchi@rics.bwh.harvard.edu
(617)525-5261
BIOGRAPHICAL SKETCH

POSITION TITLE: Research Fellow

EDUCATION:

1989 M.D. Kyushu University School of Medicine
1996 Ph.D. Kyushu University School of Medicine

PROFESSIONAL EXPERIENCE:

1989-1992 Resident in Neurology, Kyushu University School of Medicine
1992-1996 Division of Cellular biology,
Medical Institute of Bioregulation, Kyushu University
1996-1997 Department of Neurology, Kyushu University School of Medicine
1997-2000 Department of Neurology, Aso-Iizuka Hospital
2000-2005 Division of Neurofunctional Genomics,
Medical Institute of Bioregulation, Kyushu University
2005- Research Fellow in Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

PUBLICATIONS:
1. Yamaguchi H, Aiba A, Nakamura K, Nakao K, Sakagami H, Goto K, Kondo H, Katsuki M. Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells. 1996 Feb;1(2):253-68.

2. Fujii N, Furuta A, Yamaguchi H, Nakanishi K, Iwaki T. Limbic encephalitis associated with recurrent thymoma: a postmortem study. Neurology. 2001 Jul 24;57(2):344-7.

3. Yusaku Nakabeppu, Mehrdad Behmanesh, Hiroo Yamaguchi, Daisuke Yoshimura, Kunihiko Sakumi Prevention of the Mutagenecity and Cytotoxicity of Oxidized Purine Nucleotides In: M.D. Evans, M.S. Cooke (Eds.), Oxidative Damage to Nucleic Acids, Landes Bioscience/Eurekah.com, Georgetown, TX, 2006

4. Kajitani K, Yamaguchi H, Dan Y, Furuichi M, Kang D, Nakabeppu Y. MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglias during kainate-induced excitotoxicity. J Neurosci. 2006 Feb 8;26(6):1688-98.

5. Yamaguchi H, Kajitani K, Dan Y, Furuichi M, Ohno M, Sakumi K, Kang D, Nakabeppu Y. MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Cell Death Differ. 2006 Apr;13(4):551-63.

6. Nakabeppu Y, Kajitani K, Sakamoto K, Yamaguchi H, Tsuchimoto D. MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides. DNA Repair (Amst). 2006 Jul 13;5(7):761-72. Epub 2006 Apr 18. Review.

7. Nakabeppu Y, Tsuchimoto D, Yamaguchi H, Sakumi K. Oxidative damage in nucleic acids and Parkinson's disease. J Neurosci Res. 2007 Apr;85(5):919-34. Review.

8. Yamaguchi H, Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener. 2007 May 29;2:10.

9. Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6. Epub 2007 Jun 11.