Last Updated: November 2016

        The major research interests of the Shen laboratory focus on elucidation of the pathogenic mechanisms of Alzheimer’s and Parkinson’s diseases. Specifically, a multidisciplinary approach is employed to investigate the molecular and cellular mechanisms underlying pathologic degeneration of specific neuronal populations in the adult central nervous system. Through the generation and analysis of a variety of mouse models carrying mutations in the disease genes, we have identified a number of early functional impairments that may trigger the pathogenic cascade leading to neurodegeneration.